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25 Pa. Code § 250.605. Sources of toxicity information.

§ 250.605. Sources of toxicity information.

 (a)  For site-specific standards, the person shall use appropriate reference doses, reference concentrations, cancer slope factors and unit risk factors identified in Subchapter C (relating to Statewide health standards), unless the person can demonstrate that published data, available from one of the following sources, provides more current reference doses, reference concentrations, cancer slope factors or unit risk factors:

   (1)  Integrated Risk Information System (IRIS).

   (2)  United States Environmental Protection Agency, National Center for Environmental Assessment (NCEA) Provisional Peer-Reviewed Toxicity Values (PPRTV).

   (3)  Other sources:

     (i)   Health Effects Assessment Summary Tables (HEAST).

     (ii)   Agency for Toxic Substances and Disease Registry (ATSDR) Toxicological Profiles.

     (iii)   California EPA, California Cancer Potency Factors and Chronic Reference Exposure Levels.

     (iv)   EPA criteria documents, including drinking water criteria documents, drinking water health advisory summaries, ambient water quality criteria documents and air quality criteria documents.

     (v)   EPA Human Health Benchmarks for Pesticides (HHBP).

     (vi)   EPA PPRTV Appendix.

 (b)  If no toxicity values are available from sources identified in subsection (a), the person may use the background standard or meet one of the following:

   (1)  Develop for the Department’s review in the risk assessment report one of the following:

     (i)   Chemical-specific toxicity values in accordance with the methods in the most current EPA guidelines or protocols, approved by the Department, using corroborated peer-reviewed data published in a scientific journal, if they exist.

     (ii)   Toxicity values developed from appropriately justified surrogates.

   (2)  Use the minimum threshold medium-specific concentration, as the site-specific standard, with an assumed risk of 1 x 10-5 for purposes of calculating cumulative risk for the regulated substances identified in Appendix A, Table 6.


   The provisions of this §  250.605 amended under sections 104(a) and 303(a) of the Land Recycling and Environmental Remediation Standards Act (35 P.S. § §  6026.104(a) and 6026.303(a)); and section 1920-A of The Administrative Code of 1929 (71 P.S. §  510-20).


   The provisions of this §  250.605 amended January 7, 2011, effective January 8, 2011, 41 Pa.B. 230; corrected March 19, 2011, effective March 5, 2011, 41 Pa.B. 1458; amended November 19, 2021, effective November 20, 2021, 51 Pa.B. 7173. Immediately preceding text appears at serial pages (356285) to (356286).

Cross References

   This section cited in 25 Pa. Code §  250.602 (relating to risk assessment procedures); and 25 Pa. Code §  250.606 (relating to development of site-specific standards).

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